The production process of API is complex, with flammability, explosiveness, and toxicity. The hazards mainly include the following aspects:

1. Material aspect

The materials used in production are mostly flammable and explosive substances. Once the materials leak or are of poor quality, they can cause explosion accidents.

2. Equipment design and manufacturing issues

• Unreasonable design and improper arrangement of welds may cause stress concentration, and the selection of electrical equipment may not consider explosion-proof issues;
• Inadequate control over the manufacturing process has resulted in equipment quality not meeting the requirements for use by pharmaceutical companies;
• Equipment material selection error, severe corrosion, local wall thickness reduction or brittleness, reduced strength or missing safety accessories, etc;
• Violation of relevant regulations such as pressure vessel design.

3. Unreasonable layout design issues

Unreasonable design of functional areas distribution, explosion-proof area setting, HVAC design, equipment layout, etc. in the factory building can all lead to the occurrence of explosion accidents during the production process.

4. Production operations do not comply with standards

The operation personnel did not operate according to the operating procedures, and did not timely detect changes in equipment process parameters during equipment operation, such as excessive catalyst dosage or too fast feeding speed; Blindly pursuing production, equipment over pressure, overload operation, etc.

Canaan Technology understands and comes into contact with common problems of raw material manufacturing enterprises in the design and implementation of raw material engineering projects, and combines itself to make technological improvements and optimization, which are applied to every raw material engineering project we serve.

Canaan Technology’s safety measures for raw material engineering projects, starting from the design, are mainly reflected in the following aspects:

1. Ensure security from process design

The production process of active pharmaceutical ingredients has high requirements for pipeline materials, pipe diameters, connection methods, valve fittings types, valve setting points, etc. When designing, full consideration should be given to the safety accessory types, setting parameters, settings, and pipeline systems (process materials and waste water and exhaust gas pipeline systems) of valve fittings.

2. Ensure safety from the rationality of factory process layout

In process layout design, optimize the configuration of equipment layout, functional area distribution, explosion-proof area distribution, pressure relief direction area, operation and maintenance space, and evacuation routes.

3. Ensure safety in equipment design and selection

In the process of equipment design, selection, and manufacturing, attention should be paid to monitoring the working and manufacturing parameters of the equipment, especially the selection and configuration optimization of equipment and key components.

4. The project adopts three-dimensional design to ensure safety

The project engineering uses visualized 3D design and simulated installation to calibrate and optimize the pipeline system and process layout, and verify the safety and reliability of the project.

5. Optimize electrical automation control design to ensure safety

A reasonable and optimal self-control design can better ensure project safety, including project process alarms, self-control systems, online monitoring systems for waste water and exhaust gas content, and CIP/SIP self-control systems.

6. Ensure safety from the perspective of environmental regulations and requirements

From a safety perspective, catalytic oxidation and other methods are used to treat exhaust gas to meet environmental requirements.

Canaan Technology: Focus on Health Value

As a pharmaceutical equipment enterprise that shoulders social responsibility, Canaan Technology adheres to the concept of “focusing on safety and quality from the design source”, providing safe and reliable measures for customers’ raw material engineering in various aspects such as raw material supply, process control, quality control, installation and commissioning, pipeline construction, and acceptance, and safeguarding the production safety of every customer.